STUDIES ON THE REPLICATION OF MAYARO VIRUS GROWN IN INTERFERON-TREATED CELLS

Mayaro virus grown in interferon treated infected cells has been chara cterized with regard to ifs ability to replicate in vertebrate (TC7) a nd invertebrate (Aedes albopictus) cells. Virus purified from interfer on treated TC7 cells adsorbs and penetrates to the same extent as the control virus. During infection, these virus particles caused inhibiti on of host protein synthesis and synthesized the same spectrum of vira l proteins as normal virus. This population however; was apparently mo re sensitive to interferon treatment Electron microscopy of TC7 cells showed the presence of numerous aberrant virus particles budding from the plasma membrane.