2 MESENCHYMAL TUMOR-CELL LINES FOR THE ME ASUREMENT OF NATURAL-KILLER(NK) CELL-ACTIVITY IN THE PERIPHERAL-BLOOD OF DOGS

Authors
GONDOLF C KIPAR A BURKHARDT E
Citation
C. Gondolf et al., 2 MESENCHYMAL TUMOR-CELL LINES FOR THE ME ASUREMENT OF NATURAL-KILLER(NK) CELL-ACTIVITY IN THE PERIPHERAL-BLOOD OF DOGS, Berliner und Munchener Tierarztliche Wochenschrift, 108(2), 1995, pp. 47-50
Citations number
27
Categorie Soggetti
Veterinary Sciences
Journal title
Berliner und Munchener Tierarztliche Wochenschrift → ACNP
ISSN journal
00059366
Volume
108
Issue
2
Year of publication
1995
Pages
47 - 50
Database
ISI
SICI code
0005-9366(1995)108:2<47:2MTLFT>2.0.ZU;2-X
Abstract
The two mesenchymal cell lines K1 and K6 were established from round c ell tumours located at the lips of two dogs. Both cell lines were char acterized as being of myelomonocytic origin by morphological, cytochem ical, immunocytochemical and functional criteria. In the (51)chromium release assay (effector/target cell ratio 100/1) the K6-cell line reve aled a mean cytotoxic sensitivity of 53.6% and thus showed a susceptib ility similar to that of the epithelial CTAC line (57.8%). The K1-cell line exhibited less cytotoxic activity (41%) when incubated for 14 h, but showed results comparable to the K6-cell line, when the incubatio n time was reduced to 8 h.