TOPICAL TREATMENT OF PSORIASIS WITH CYCLO SPORINE EXPERIENCE IN 8 PATIENTS

In eight patients with chronic and stable psoriasis, the usefulness of topical cyclosporine solution using 50% dimethylsulfoxide as a vehicl e was assessed in a randomly chosen plate and compared with a similar solution without cyclosporine in a contralateral plate. After six mont hs of treatment the plates involuted in two patients, and in the rest there was a I to 3 points reduction in the local psoriasis area severi ty index score. Plasma cyclosporine levels were negligible and no chan ges in blood chemistry were detected. It is concluded that topical cyc losporine is effective in the treatment of psoriasis, but only after a prolonged application period