LETHAL CONGENITAL NON-SPHEROCYTIC, NONIMMUNE HEMOLYTIC-ANEMIA WITH GENITAL AND OTHER ANOMALIES IN 2 BROTHERS

Non-consanguineous healthy parents had 2 boys with severe, non-spheroc ytic, nonimmune hemolytic anemia, abnormalities of their external geni talia, flat occiput, dimpled earlobes, deep plantar creases, and incre ased space between their first and second toes. The birth of these chi ldren was separated by a spontaneous abortion at 3 months and delivery of a normal girl. We propose that these boys have a heretofore undesc ribed autosomal or X-linked recessive syndrome. (C) 1995 Wiley-Liss, I nc.