Y. Mizushima et al., ASSOCIATION BETWEEN GENE ALTERATION AND DRUG-SENSITIVITY IN HUMAN LUNG-CARCINOMA CELL-LINES, Oncology Reports, 2(2), 1995, pp. 277-280
The association between gene alterations (K-ras, p53, N-myc) and drug
resistance (CDDP, CBDCA, MMC, Epi-ADM) was examined in 29 human lung c
arcinoma cell lines using the in vitro MTT assay. There was no signifi
cant difference in the IC50 values of four drugs between K-ras or p53
gene alteration-positive and -negative groups. However, two cell lines
with N-myc amplification showed a higher resistance than those withou
t N-myc amplification to all four drugs. This preliminary study sugges
ts that K-ras or p53 gene alteration is probably not related to drug r
esistance, but N-myc might be.