P. Popowicz et al., DIFFERENTIAL-EFFECTS OF FIBROBLAST COCULTURE ON MCF-7 AND MDA-231 BREAST-CARCINOMA CELL INVASION THROUGH MATRIGEL, Oncology Reports, 2(2), 1995, pp. 303-306
The stimulative effect of conditioned media collected from fibroblasts
or breast epithelial cells on breast carcinoma cell invasion through
Matrigel was studied. Fibroblast conditioned medium was more efficient
than media collected from breast epithelial cells in stimulating chem
oinvasion of highly invasive MDA-MB-231 and MDA-MB-436 cells. In contr
ast, fibroblast conditioned medium was found to be less effective than
breast epithelial cell conditioned medium in stimulating invasion of
weakly metastatic MCF-7 cells. These data suggest that fibroblasts pre
ferentially enhance the invasive capacity of highly malignant breast c
arcinoma cells.