CEFTRIAXONE VERSUS CEFAZOLIN IN PERIPHERAL ARTERIAL OPERATIONS - A RANDOMIZED, PROSPECTIVE TRIAL

Serious morbidity and mortality are associated with postoperative woun d infections in peripheral vascular surgery, The use of prophylactic a ntibiotics is considered the standard of care, with attention focused on the most efficacious agent, A prospective, randomized study was con ducted to evaluate the efficacy of ceftriaxone versus cefazolin in pre vention of postoperative wound infections in a group of patients who h ad peripheral arterial operations between October 1991 and February 19 93, Patient characteristics associated with an increased risk of posto perative wound infection were evaluated, Prophylaxis was provided for 105 operations with cefazolin and 103 operations with ceftriaxone, The overall wound infection rate was 3.85%. Six operations (5.7%) in the cefazolin group were complicated by wound infection versus 2 operation s (1.9%) in the ceftriaxone group, Diabetes (6 infections/64 operation s; infection rate, 9%) and a personal history of previous aortocoronar y bypass (5 infections/49 operations; infection rate, 10%) were charac teristics associated with an increased chance for postoperative wound infection, Ceftriaxone is therapeutically equivalent to cefazolin in t he prevention of postoperative wound infections in peripheral vascular surgery.