THE ROLE OF LIPOPROTEIN A-I AND LIPOPROTEIN A-I A-II IN PREDICTING CORONARY-ARTERY DISEASE/

The aim of this study was to examine the role of HDL subparticles with apolipoprotein (ape) A-I alone (LpA-I) and with apoA-I and apoA-II (L pA-I/A-II) in predicting coronary artery disease. Concentrations of th ese HDL subparticles were compared in 184 subjects with angiographical ly confirmed significant coronary artery disease (>50% stenosis of at least one vessel) and 191 age- and sex-matched control subjects withou t clinical coronary artery disease. LpA-I and LpA-I/A-II were measured with magnetic beads coated with anti-apoA-II antibodies to separate p articles containing apoA-II from plasma. Total plasma cholesterol and triglyceride levels were similar in both groups. Although subjects wit h coronary artery disease had lower HDL cholesterol, plasma apoA-I, Lp A-I, and LpA-I/A-II than age- and sex-matched control subjects without coronary artery disease, plasma apoA-I was the best predictor of coro nary artery disease. In conclusion, LpA-I and LpA-I/A-II are lower in subjects with coronary artery disease but do not add to plasma apoA-I in predicting the presence of coronary artery disease.