HYPERSENSITIVITY TO AZATHIOPRINE MIMICKING GASTROENTERITIS - ABSENCE OF RECURRENCE WITH B-MERCAPTOPURINE

Authors
GODEAU B PAUL M AUTEGARDEN JE LEYNADIER F ASTIER A SCHAEFFER A
Citation
B. Godeau et al., HYPERSENSITIVITY TO AZATHIOPRINE MIMICKING GASTROENTERITIS - ABSENCE OF RECURRENCE WITH B-MERCAPTOPURINE, Gastroenterologie clinique et biologique, 19(1), 1995, pp. 117-119
Citations number
12
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
Gastroenterologie clinique et biologique → ACNP
ISSN journal
03998320
Volume
19
Issue
1
Year of publication
1995
Pages
117 - 119
Database
ISI
SICI code
0399-8320(1995)19:1<117:HTAMG->2.0.ZU;2-E
Abstract
Hypersensitivity mimicking gastroenteritis is a rare complication of a zathioprine therapy for which the mechanism is unknown. We report a ca se of devastating diarrhoea and vomiting due to azathioprine treatment in which hypersensitivity to the imidazole moiety of azathioprine was demonstrated. This has important therapeutic implications in this sit uation, 6-mercaptopurine, which is the portion of azathioprine respons ible for the cytotoxic therapeutic effect, can be administered without recurrence of side-effects.