We report the association of primary sclerosing cholangitis and system
ic lupus erythematosus in a 39 year-old man. Six months after a diagno
sis of primary sclerosing cholangitis was established, the patient was
hospitalized for a pleural effusion and acute pericarditis. Emergency
pericardiocentesis, was required due to sudden cardiac tamponnade. Pl
asmatic anti-DNA and anti-nuclear antibodies were present. Treatment b
y steroids greatly improved symptoms. This clinical association sugges
ts that some immune disorders may be common to the two diseases.