FIRST REPORT OF T(8-21)(Q22-Q22) IN A CASE OF DE-NOVO ACUTE MONOBLASTIC LEUKEMIA

Here we describe the case of a 30-year-old man with a diagnosis of de novo acute monoblastic leukemia (FAB M5a), whose karyotype analysis re vealed the presence of the translocation (8;21)(q22;q22) as the sole c hromosome anomaly. In spite of the rather good prognosis patients suff ering from acute leukemia and carrying this translocation are supposed to have, our patient had a very poor outcome, including an early rela pse resistant to any treatment and meningeal localization. Death occur red within 5 months from diagnosis. To our knowledge this is the first report of t(8;21)(q22;q22) in de novo acute monoblastic leukemia.