Pg. Merz et al., THE EFFECTS OF A SPECIAL AGNUS-CASTUS EXTRACT (BP1095E1) ON PROLACTINSECRETION IN HEALTHY MALE-SUBJECTS, EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 104(6), 1996, pp. 447-453
The effects of three doses of a special Agnus castus extract (BP1095E1
) - extracts from 120 mg, 240 mg and 480 mg of drug per day - were exa
mined within the framework of a placebo-controlled clinical study of t
olerance and prolactin secretion in 20 healthy male subjects during a
period of 14 days. There was good tolerance during the study as regard
s the following: adverse effects, the effects on blood pressure and he
art rate, blood count, Quick's test, clinical chemistry as well as tes
tosterone, FSH and LH values. During each study phase the 24-hour prol
actin secretion profile was measured from the penultimate to the final
day, and the amount of prolactin release was monitored an hour after
TRH stimulation on the last day. A significant increase in the 24-hour
profile was registered with the lowest dose in comparison to placebo,
the opposite being the case with the higher doses, i.e. a slight redu
ction. In contrast to the administration of placebo, the 1-hour AUC af
ter TRH stimulation resulted in a significant increase with the lowest
dose and a significant reduction with the highest dose. The results s
uggest effects of the special Agnus castus extract which are dependent
on the dose administered and the initial level of prolactin concentra
tion.