SYNTHESIS OF 2,3-DISUBSTITUTED-3,1-QUINAZOLIN-4(4H)-ONES AS POTENTIALANTICANCER AND ANTI-HIV AGENTS

Authors
SHAH BR BHATT JJ PATEL HH UNDAVIA NK TRIVEDI PB DESAI NC
Citation
Br. Shah et al., SYNTHESIS OF 2,3-DISUBSTITUTED-3,1-QUINAZOLIN-4(4H)-ONES AS POTENTIALANTICANCER AND ANTI-HIV AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(3), 1995, pp. 201-208
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
3
Year of publication
1995
Pages
201 - 208
Database
ISI
SICI code
0376-4699(1995)34:3<201:SO2AP>2.0.ZU;2-U
Abstract
Several ro-4-arylidine-5-oxo-2-phenyl-1H-imidazol-1-yl)-2- phenyl-4(3H )-oxoquinazolines (4a-l), enyl-4(3H)-oxo-3-quinazolinylamino]-N-substi tuted- arylacetamides (5a-n), oxo-2-phenylquinazolin-3-yl]aminocarboph enyl}-N-2- alkyl/arylthioureas (7a-h), 3H)-oxo-2-phenylquinazolin-3-yl ]-N-2-arylthioureas (8a-l) and N-1-{4-[4(3H)-oxo-2-phenylquinazolin-3- yl] abminocarbophenyl}-N-2-carboaryl/aryloxythioureas (11a-h) have bee n synthesized and tested for their antibacterial, antitubercular, anti cancer and anti-HIV activities. The structures of these compounds have been established on the basis of elemental analyses and spectral data .