STUDIES IN ANTIPARASITIC AGENTS .24. SYNTHESIS OF 5-(2-FURYL)-2-SUBSTITUTED-AMINO-1,3,4-TRIAZOLES AND SUBSTITUTED 1,3,4-TRIAZOLES[1,5-A]PYRIMIDINES AS POTENTIAL ANTIFILARIAL AND LEISHMANICIDAL AGENTS

A series of 5-(2-furyl)-2-substituted-amino-1,3,4-triazoles (3-5) and 2-(2-furyl)-1,3,4-triazolo[1,5-a]Pyrimidines (6, 9-19) have been synth esized as possible inhibitors of antioxidant enzymes in filariids and leishmanial parasites. All the compounds have been evaluated for their antifilarial and antileishmanial activities. The antifilarial activit y has been evaluated against Litomosoides carinii infection in cotton rats while the in vitro leishmanicidal activity determined using macro phage amastigote culture isolated from cotton rats infected with Leish mania donovani. In both the tests none of the compounds exhibits any n oteworthy antiparasitic activity.