STUDIES IN ANTIPARASITIC AGENTS .24. SYNTHESIS OF 5-(2-FURYL)-2-SUBSTITUTED-AMINO-1,3,4-TRIAZOLES AND SUBSTITUTED 1,3,4-TRIAZOLES[1,5-A]PYRIMIDINES AS POTENTIAL ANTIFILARIAL AND LEISHMANICIDAL AGENTS
Rp. Srivastava et al., STUDIES IN ANTIPARASITIC AGENTS .24. SYNTHESIS OF 5-(2-FURYL)-2-SUBSTITUTED-AMINO-1,3,4-TRIAZOLES AND SUBSTITUTED 1,3,4-TRIAZOLES[1,5-A]PYRIMIDINES AS POTENTIAL ANTIFILARIAL AND LEISHMANICIDAL AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(3), 1995, pp. 209-214
A series of 5-(2-furyl)-2-substituted-amino-1,3,4-triazoles (3-5) and
2-(2-furyl)-1,3,4-triazolo[1,5-a]Pyrimidines (6, 9-19) have been synth
esized as possible inhibitors of antioxidant enzymes in filariids and
leishmanial parasites. All the compounds have been evaluated for their
antifilarial and antileishmanial activities. The antifilarial activit
y has been evaluated against Litomosoides carinii infection in cotton
rats while the in vitro leishmanicidal activity determined using macro
phage amastigote culture isolated from cotton rats infected with Leish
mania donovani. In both the tests none of the compounds exhibits any n
oteworthy antiparasitic activity.