THE ACTIVITIES OF 4 ANTICANCER ALKYLLYSOPHOSPHOLIPIDS AGAINST LEISHMANIA-DONOVANI, TRYPANOSOMA-CRUZI AND TRYPANOSOMA-BRUCEI

Authors
CROFT SL SNOWDON D YARDLEY V
Citation
Sl. Croft et al., THE ACTIVITIES OF 4 ANTICANCER ALKYLLYSOPHOSPHOLIPIDS AGAINST LEISHMANIA-DONOVANI, TRYPANOSOMA-CRUZI AND TRYPANOSOMA-BRUCEI, Journal of antimicrobial chemotherapy, 38(6), 1996, pp. 1041-1047
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
38
Issue
6
Year of publication
1996
Pages
1041 - 1047
Database
ISI
SICI code
0305-7453(1996)38:6<1041:TAO4AA>2.0.ZU;2-3
Abstract
The in-vitro activities of four anticancer alkyllysophospholipids, ET- 18-OCH3 (edelfosine), hexadecylphosphocholine (miltefosine), ilmofosin e and SRI 62-834, were determined with ED(50) values for Leishmania do novani and Trypanosoma cruzi amastigotes between 0.2 and 5.0 mu M and for Trypanosoma brucei trypomastigotes between 7.0 and 50.8 mu M. In B ALB/c mice miltefosine and ilmofosine were the most active compounds w ith ED(50) values of 2.9 and 14.5 mg/kg x 5 doses against L. donovani and a suppressive effect on T. cruzi infections at 30 mg/kg x 5 doses.