THE EVALUATION OF 2',3'-DIDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSLY NUCLEOSIDES AS POTENTIAL ANTISENSE CONSTRUCTS - SYNTHESIS, BIOPHYSICAL PROPERTIES AND ENZYMATIC STABILITY OF IDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSYL)THYMINE] PHOSPHATE

Authors
TARI LW SADANA KL SECCO AS
Citation
Lw. Tari et al., THE EVALUATION OF 2',3'-DIDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSLY NUCLEOSIDES AS POTENTIAL ANTISENSE CONSTRUCTS - SYNTHESIS, BIOPHYSICAL PROPERTIES AND ENZYMATIC STABILITY OF IDEOXY-BETA-D-ERYTHRO-HEX-2'-ENOPYRANOSYL)THYMINE] PHOSPHATE, Nucleosides & nucleotides, 14(1-2), 1995, pp. 175-183
Citations number
8
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
1-2
Year of publication
1995
Pages
175 - 183
Database
ISI
SICI code
0732-8311(1995)14:1-2<175:TEO2N>2.0.ZU;2-L
Abstract
dideoxy-beta-D-erythro-hex-2'-enopryanosyl)thymine was used as a nucle oside substitute in the synthesis of the dimer ApT. CD studies on the dimer show that it adopts stacked, B-form mini-helices in solution. T he title compound, relative to natural ApT, possesses an increased res istance to degradation by nucleases.