SYNTHESIS OF (+ -1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]CYTOSINE AND ITS (+/-)-TRANS ISOMER/

Authors
HUANG JJ RIDEOUT JL MARTIN GE
Citation
Jj. Huang et al., SYNTHESIS OF (+ -1-[2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL]CYTOSINE AND ITS (+/-)-TRANS ISOMER/, Nucleosides & nucleotides, 14(1-2), 1995, pp. 195-207
Citations number
48
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
1-2
Year of publication
1995
Pages
195 - 207
Database
ISI
SICI code
0732-8311(1995)14:1-2<195:SO(-A>2.0.ZU;2-I
Abstract
The title compounds were synthesized by the formation of 2-[(benzyloxy )methyl] -1,3-oxathiolan-5-one and subsequent DIBALH reduction, acetyl ation, coupling with 1,2-dihydro-2-oxo-4-pyrimidinyl)-2-ethylhexanamid e and deprotection.