PREPARATION OF OLIGOMERIC 2'-DEOXY-5-FLUOROURIDYLATE OF DEFINED LENGTH AND BACKBONE COMPOSITION - A NOVEL PRO-DRUG FORM OF THE POTENT ANTICANCER DRUG 2'-DEOXY-5-FLUOROURIDYLATE

Authors
GMEINER WH SAHASRABUDHE P PON RT SONNTAG J SRINIVASAN S IVERSEN PL
Citation
Wh. Gmeiner et al., PREPARATION OF OLIGOMERIC 2'-DEOXY-5-FLUOROURIDYLATE OF DEFINED LENGTH AND BACKBONE COMPOSITION - A NOVEL PRO-DRUG FORM OF THE POTENT ANTICANCER DRUG 2'-DEOXY-5-FLUOROURIDYLATE, Nucleosides & nucleotides, 14(1-2), 1995, pp. 243-253
Citations number
16
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
1-2
Year of publication
1995
Pages
243 - 253
Database
ISI
SICI code
0732-8311(1995)14:1-2<243:POO2OD>2.0.ZU;2-Y
Abstract
A recursive protection scheme for FdUMP is employed by synthesizing ol igonucleotides consisting of only FdU. 3'-O-exonuclease action release s FdUMP and a shortened oligonucleotide from which further exonuclease action releases more FdUMP. Such oligonucleotides are more cytotoxic to H4IIe, mouse fibroblast, and metastatic mouse tumor cells than are equivalent concentrations of FdU monomer.