Dm. Green et al., IN-SITU BREAST-CARCINOMA AFTER TREATMENT DURING ADOLESCENCE FOR THYROID-CANCER WITH RADIOIODINE, Medical and pediatric oncology, 24(2), 1995, pp. 82-86
We reviewed the courses of patients treated during childhood or adoles
cence for thyroid cancer to estimate the frequency of, and to identify
possible risk factors for, the occurrence of second malignant tumors
in this population. We identified all patients treated for thyroid can
cer in a cohort of 1,406 pediatric cancer patients who were diagnosed
prior to 20 years of age during the period January 1, 1960 through Dec
ember 31, 1988 and who were treated at Roswell Park Cancer Institute.
Twelve patients were treated for thyroid cancer, of whom nine were wom
en. In situ breast carcinoma was diagnosed 25 and 26 years after diagn
osis of thyroid cancer in two of four women treated with radioiodine.
No new cancers were diagnosed in the five women treated with thyroidec
tomy only. Two of four women treated for thyroid cancer during adolesc
ence with radioiodine, which is concentrated in the breast as well as
other organs, developed in situ breast carcinoma. Review of a large co
hort of adolescent female thyroid cancer patients treated with radioio
dine is necessary to provide an accurate estimate of their risk of dev
eloping breast cancer. These patients must remain under medical survei
llance throughout their lifetimes to facilitate prompt diagnosis of an
d early intervention for new conditions, such as the occurrence of bre
ast cancer. (C) 1995 Wiley-Liss, Inc.