INCREASED RENAL PARENCHYMAL ECHOGENICITY IN IFOSFAMIDE-INDUCED RENAL FANCONI SYNDROME

Three children who presented with a Fanconi syndrome induced by the ch emotherapeutic drug ifosfamide were found to have renal abnormalities on sonogram examinations. Renal echographic changes consisted in hyper echogenicity of the parenchyma with good corticomedullar differentiati on. After discontinuation of the chemotherapy, the serum and urine met abolic abnormalities due to proximal tubulopathy were completely or gr eatly improved. Imaging studies at that time showed a complete resolut ion of the renal hyperechogenicity. We suggest that in patients expose d to ifosfamide, renal sonogram may be of value to monitor the tubular toxicity of this drug. In these patients, urine and serum monitoring as well as prospective echographic follow-up kidney abnormalities may lead to earlier detection of ifosfamide-induced Fanconi syndrome as we ll as earlier detection of disease reversibility. (C) 1995 Wiley-Liss, Inc.