ACUTE URTICARIA AND HEPATITIS COMPLICATING HIGH-DOSE METHOTREXATE THERAPY

We report an unusual case of anaphylaxis and hepatitic dysfunction in a child with the administration of the twenty-third course of high-dos e methotrexate. The latter had been used as an adjuvant to prevent pul monary metastases and the prior 22 courses had been well tolerated. An attempt to reinstate methotrexate after the twenty-third course was a gain followed by a similar reaction. (C) 1995 Wiley-Liss, Inc.