In the diagnostic armamentarium of neurological disorders, clinical ne
urophysiology has attained a critical role as it provides useful infor
mation on the functional integrity of the central and peripheral nervo
us system and localization of the lesion. With sophistication of instr
umentation, major advances in electronics and computer technology have
been translated into clinical application, facilitating a more precis
e understanding of the functional state of the nervous system. The non
invasive approach of many of the electrophysiological procedures, like
electroencephalography, electromyography, nerve conduction and evoked
potential studies, has made them acceptable in routine clinical pract
ice for evaluating the functional status of brain, special sensory, mo
tor and somatic sensory pathways, peripheral nerves, neuromuscular jun
ction and muscle in various states of health and disease. In the recen
t years, for studying the central motor pathways, electrical stimulati
on has been replaced by magnetic stimulation. Another new development,
still under evaluation, is magnetoencephalography, which recognizes a
tangentially oriented electrical source and may become a complementar
y tool to the conventional electroencephalography. In the Indian conte
xt, there is an urgent need for a closer interaction of the scientists
in the fields of basic physical sciences and neurosciences to foster
mutual growth and promote new developments in clinical neurophysiology
.