NEURAL-TUBE DEFECTS AND MATERNAL WEIGHT-REDUCTION IN EARLY-PREGNANCY

We present data from a case series in France of pregnant women who los t 2 to 14 kg during the first month after conception and whose fetuses developed neural tube defects (NTDs), Preliminary epidemiologic evide nce from other data sets suggest that relative lack of weight gain dur ing pregnancy may be associated with NTDs, The role of starvation, dia betes, and valproic acid in the etiology of NTDs is established, This etiologic information coupled with our data suggest an hypothesis that ketoacidosis induced by weight loss in early pregnancy is a risk fact or for NTDs.