ALLOGENEIC PERIPHERAL-BLOOD PROGENITOR CELLS MOBILIZED BY G-CSF (FILGRASTIM) FOR A 2ND TRANSPLANT IN A PATIENT WITH ACUTE MYELOID-LEUKEMIA IN RELAPSE

A 25-year old man with AML, who relapsed 21 months after his first all ogeneic bone marrow transplant (BMT), underwent a second transplant wi th peripheral blood progenitor cells (PBPC) obtained from his HLA-iden tical sibling, The donor cells were collected through four aphereses a fter G-CSF mobilization with 5 mu g/kg/d for 5 days, The patient recei ved BAVC conditioning regimen followed by non-T cell-depleted PBPC, Su ccessful engraftment occurred with rapid hematopoietic recovery (time to reach 0.5x10(9)/L neutrophils and 50x10(9) platelets/L was 15 and 1 9 days, respectively), A bone marrow aspirate on day +19 showed trilin eage engraftment, Erythrocyte phenotype showed that erythropoiesis was of donor origin, The patient developed grade II acute GVHD that respo nded to prednisone, Seven months after PBPC transplantation he remains in complete remission, alive and well, with just limited chronic GVHD , Allogeneic peripheral blood progenitor cell transplantation may be c onsidered a suitable alternative to marrow transplant.