RED-CELL PRESERVATIVE ON THE BASE OF MODI FIED DEIONIZED GELATIN SOLUTION WITH ADENINE AND SODIUM-PHOSPHATE

Hematology and Blood Transfusion Institute, St.-Petersburg, Russia. Th e paper reports storage properties of a new erythropreservative made o f the solution of modified deionized gelatin with addition of adenin a nd disodium phosphate. 42-day storage of red cell suspension in the ab ove preservative was assessed in comparison to Modejele preservative a ccording to the following characteristics: free hemoglobin, the count of osmotically unstable red cells, red cell ATP concentration, red cel l deformability index, zeta-potential, extracellular potassium and sod ium concentrations, amount of microclots, acid-base condition of the s uspensions, blood rheology. Control and test parameters showed the gre atest difference by ATP concentrations: on storage day 42 ATP in the c ontrols made up 58,9% in the test series 77.8% against the baseline. R ed cell deformability under storage in the new preservative also tende d to a decrease. The rest test parameters did not differ much in the c ontrol and test series. Acute mouse, chronic rat, rabbit and dog exper iments proved low toxicity of the perservative. The repeated introduct ion of the preparation brought about a slight shift to hypercoagulatio n.