CLINICOIMMUNOLOGICAL EFFECT OF TACTIVIN I N CHRONIC MYELOID-LEUKEMIA

Authors
ABDULKADYROV KM GUSEVA SA
Citation
Km. Abdulkadyrov et Sa. Guseva, CLINICOIMMUNOLOGICAL EFFECT OF TACTIVIN I N CHRONIC MYELOID-LEUKEMIA, Gematologia i transfuziologia, 39(5), 1994, pp. 19-22
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
39
Issue
5
Year of publication
1994
Pages
19 - 22
Database
ISI
SICI code
0234-5730(1994)39:5<19:CEOTIN>2.0.ZU;2-0
Abstract
Immunological reactivity and factors of nonspecific body defense were studied in 35 patients with advanced chronic myeloid leukemia (CML). P rior to cytostatic therapy, CML patients have secondary combined immun odeficiency manifesting by inhibition of T-system immunity and phagocy tic neutrophil activity. Repeated courses of myelosan chemotherapy agg ravate the above immune defects. The adjuvant immunomodulator tactivin corrects cellular immunity and reduces the occurrence of infectious c omplications 1.77-fold.