TACTIVIN ACTION ON CYTOTOXICITY OF LYMPHO CYTES FROM PATIENTS WITH CHRONIC MYELOPROLIFERATIVE DISEASES

Authors
GUSEVA SA
Citation
Sa. Guseva, TACTIVIN ACTION ON CYTOTOXICITY OF LYMPHO CYTES FROM PATIENTS WITH CHRONIC MYELOPROLIFERATIVE DISEASES, Gematologia i transfuziologia, 39(5), 1994, pp. 22-25
Citations number
NO
Categorie Soggetti
Hematology
Journal title
Gematologia i transfuziologia → ACNP
ISSN journal
02345730
Volume
39
Issue
5
Year of publication
1994
Pages
22 - 25
Database
ISI
SICI code
0234-5730(1994)39:5<22:TAOCOL>2.0.ZU;2-D
Abstract
The author studied natural cellular cytotoxicity (NCC) and antibody-de pendent cytotoxicity (ADC) in lymphocytes from 31 patients with chroni c myeloid leukemia (CML) and 37 patients with subleukemic myeloleukemi a (SLM) in active clinical stage. The above parameters were found low in both diseases. Cytostatic therapy for CML did not affect NCC, but i nhibited ADC. SLM treatment with myelobromol inhibited both cytotoxic responses. Combined therapy with adjuvant tactivin stimulated cytotoxi c reactions activity. Tactivin positive effects persisted for two mont hs.