Objective: The relationship between tobacco dependence and alcohol dep
endence has received little empirical scrutiny. The present study of a
lcoholics in treatment for alcoholism investigated pre-treatment tobac
co and alcohol history and dependence, as well as subjective responsiv
ity to alcohol cues. Method: Eighty-three male alcoholics underwent a
questionnaire assessment of smoking and drinking pretreatment followed
by a laboratory assessment of reactivity to alcohol cues. Results: Th
e analyses demonstrate that (1) pretreatment tobacco dependence and pr
etreatment alcohol dependence are related, (2) alcohol dependence pred
icts urges to smoke during alcohol treatment, (3) exposure to alcohol
cues results in increased urge to smoke, (4) smoking when ill predicts
urge to drink during alcohol cue exposure and (5) urge to smoke is po
sitively correlated with urge to drink. Conclusions: These data, colle
cted in a population of alcoholics not currently receiving smoking int
erventions, indicate that smoking may be a factor to address during al
cohol treatment. The clinical importance of these data is discussed.