BACCATIN-III DERIVATIVES - REDUCTION OF THE C-11,C-12-DOUBLE-BOND

Authors
MARDER R DUBOIS J GUENARD D GUERITTEVOEGELEIN F POTIER P
Citation
R. Marder et al., BACCATIN-III DERIVATIVES - REDUCTION OF THE C-11,C-12-DOUBLE-BOND, Tetrahedron, 51(7), 1995, pp. 1985-1994
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
7
Year of publication
1995
Pages
1985 - 1994
Database
ISI
SICI code
0040-4020(1995)51:7<1985:BD-ROT>2.0.ZU;2-N
Abstract
Zinc-promoted reduction of 13-oxobaccatin III derivatives leads to 11, 12-dihydro analogs. The reduced products are unstable and a skeleton r earrangement occurs leading to the cleavage of the C-10, C-11 bond. Th e 11,12-dihydrobaccatin III derivatives do not retain antitubulin acti vity.