A NOVEL FORM OF MOUSE CYTOCHROME-P450 3A (CYP3A-16) - ITS CDNA CLONING AND EXPRESSION IN FETAL LIVER

Authors
ITOH S SATOH M ABE Y HASHIMOTO H YANAGIMOTO T KAMATAKI T
Citation
S. Itoh et al., A NOVEL FORM OF MOUSE CYTOCHROME-P450 3A (CYP3A-16) - ITS CDNA CLONING AND EXPRESSION IN FETAL LIVER, European journal of biochemistry, 226(3), 1994, pp. 877-882
Citations number
48
Categorie Soggetti
Biology
Journal title
European journal of biochemistry → ACNP
ISSN journal
00142956
Volume
226
Issue
3
Year of publication
1994
Pages
877 - 882
Database
ISI
SICI code
0014-2956(1994)226:3<877:ANFOMC>2.0.ZU;2-L
Abstract
A complementary DNA clone coding for a novel form of cytochrome P450, Cyp3a-16, in mouse fetal livers was isolated and completely sequenced. This clone encoded a polypeptide of 504 deduced amino acids and showe d 87.3% and 66.6% amino acid identities with mouse Cyp3a-11 and Cyp3a- 13, respectively. Cyp3a-16 transcript was detectable before birth and remarkably diminished five weeks after birth in mice. We conclude that Cyp3a-16 is a fetal- and puberty-specific cytochrome P450 in mice.