T-CELL ANTIGEN RECEPTOR-INDUCED SIGNAL-TRANSDUCTION PATHWAYS - ACTIVATION AND FUNCTION OF PROTEIN KINASES-C IN T-LYMPHOCYTES

CONTENTS. T-cell activation - Structure of the T-cell antigen receptor - Modular organisation of the T-cell antigen receptor - T-cell antige n receptor-coupled signaling pathways: Activation of protein-tyrosine kinase by the T-cell antigen receptor; Signal transduction in lymphoid cells involves several protein-tyrosine kinases in parallel; Regulati on of T-cell antigen receptor signaling by the phosphoprotein phosphat ase CD45 - Consequences of T-cell antigen receptor-induced tyrosine ph osphorylation: Activation of phosphoinositol-lipid-turnover pathways - Activation of phospholipase C-gamma-1: p59(fyn) or p56(lck)? - G-prot ein motif of CD3-gamma relevance for signal transduction - Association of lipid kinase with the T-cell antigen receptor - Intracellular sign aling by phospholipid metabolites and calcium: activation of protein k inase C - Protein kinase C isoenzymes - Heterogenity of protein kinase C and mode of activation - Phospholipid-derived mediators in activati on of protein kinase C in T-cells - Role of phospholipase D metabolite s in activation of protein kinase C - Polyunsaturated fatty acids and lysophosphatidylcholine as activators of protein kinase C - Protein ki nase C and p21(ras) function in interdependent and distinct signaling pathways during T-cell activation Raf-l kinase: regulator or target of protein kinase C? - Summary and perspectives.