I. Hatin et G. Jaureguiberry, MOLECULAR CHARACTERIZATION OF THE ADP ATP-TRANSPORTER CDNA FROM THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM/, European journal of biochemistry, 228(1), 1995, pp. 86-91
We have isolated a cDNA sequence encoding the ADP/ATP transporter in P
lasmodium falciparum. The sequence analysis revealed an open reading f
rame encoding 301 amino acids and showed significant similarities to k
nown eukaryotic translocases such as that of Chlorella (up to 67.2% id
entity) acid the human transporter (61.2%). RNA blot analysis showed t
he presence of mRNA encoding for a 33.7-kDa ADP/ATP transporter. Durin
g the cell cycle of the parasite the expression levels of the transcri
pts fluctuate. The mitochondrial ADP/ATP transporter could play a role
in energy metabolism of P. falciparum and makes this transporter an e
xcellent target for chemotherapy.