APOLIPOPROTEIN-E GENOTYPE AND LATE PARAPHRENIA

Patients with late paraphrenia or late onset schizophrenia frequently have associated cognitive impairment which may in some cases progress to a recognized dementia. The frequency of the apoE epsilon 4 allele i s high in individuals who develop Alzheimer's disease. Twenty-three pa tients with late paraphrenia were genotyped for ApoE. The frequency of the epsilon 4 allele was comparable with that found in a large group of centenarians, but lower than previously reported from populations o f normal controls and Alzheimer's disease patients. Two out of three m ale patients tested had the rare epsilon 2/epsilon 2 genotype, which w as not found in any of the females.