CORRELATION OF MONO AND COMBINED AMITRIPTYLINE LITHIUM-THERAPY WITH THERAPEUTIC AND SIDE-EFFECTS

Authors
TIMOTIJEVIC I ZDRAVKOVIC M POKRAJAC M MILJKOVIC B STOJKOVIC M MARINKOVIC O
Citation
I. Timotijevic et al., CORRELATION OF MONO AND COMBINED AMITRIPTYLINE LITHIUM-THERAPY WITH THERAPEUTIC AND SIDE-EFFECTS, Journal of trace and microprobe techniques, 13(1), 1995, pp. 11-20
Citations number
22
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of trace and microprobe techniques → ACNP
ISSN journal
07334680
Volume
13
Issue
1
Year of publication
1995
Pages
11 - 20
Database
ISI
SICI code
0733-4680(1995)13:1<11:COMACA>2.0.ZU;2-Y
Abstract
The role of lithium in combination with tricyclic antidepressants (TCA ) used in the treatment of unipolar depression has been much less stud ied than in the case of bipolar disorders. The aim of this study was t o compare the therapeutic and side effects with doses and plasma conce ntrations in the patients with major (unipolar) depression (DSM-III-R criteria) treated by amitriptyline combine (At + Li) and mono-therapy. All three of these regiments were therapeutically effective, but afte r six weeks combined (At + Li) therapy showed the absence of the incre ased number of side effects.