TRANSFORMATION OF 1,4-DIHYDROPYRIDINE RING OF CALCIUM-ANTAGONIST NZ-105 INTO CYCLOHEXENONE RING

Authors
KAMIKAWAJI Y SAKODA R SETO K
Citation
Y. Kamikawaji et al., TRANSFORMATION OF 1,4-DIHYDROPYRIDINE RING OF CALCIUM-ANTAGONIST NZ-105 INTO CYCLOHEXENONE RING, Chemical and Pharmaceutical Bulletin, 43(2), 1995, pp. 315-317
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
2
Year of publication
1995
Pages
315 - 317
Database
ISI
SICI code
0009-2363(1995)43:2<315:TO1ROC>2.0.ZU;2-I
Abstract
On hydrolysis of the calcium antagonist, 2-(N-benzyl-N-phenylamino)eth yl ,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimet hydrochloride et hanol (NZ-105 1 . HCl . EtOH) in 35% hydrochloric acid, the 1,4-dihydr opyridine ring was transformed to a cyclohexenone ring, affording the cyclohexenonephosphonates 2 and 3.