RAS GENE-MUTATIONS IN CHINESE LEUKEMIA PATIENTS AND MEMBERS OF A FAMILY WITH HIGH-INCIDENCE OF LEUKEMIA

We investigated mutations of N-RAS and K-RAS by using polymerase chain reaction (PCR)-oligonucleotide hybridization techniques in 40 cases o f Chinese leukaemia patients and 17 presently healthy members of a fam ily with high incidence of acute myeloid leukaemia. The results showed only two patients carried the mutation in codon 12 of N-RAS. Striking ly, however, in both cases the malignancies involved lymphoid lineage. There was no hereditary RAS mutation in the members of the remarkable family, Copyright (C) 1996 Elsevier Science Ltd