M. Yamaguchi et al., NOVEL ANTIASTHMATIC AGENTS WITH DUAL ACTIVITIES OF THROMBOXANE A(2) SYNTHETASE INHIBITION AND BRONCHODILATION .6. INDAZOLE DERIVATIVES, Chemical and Pharmaceutical Bulletin, 43(2), 1995, pp. 332-334
Synthesis and pharmacological evaluation of novel indazole derivatives
are described, These compounds were found to exhibit both thromboxane
A(2) (TXA(2)) synthetase-inhibitory and bronchodilatory activities, T
his observation supports the idea that the partial structure of the 3-
pyridyl and phenyl groups with a methylene insertion is an important c
omponent for well-balanced activities,