NOVEL FLUOROPROSTACYCLIN ANALOGS WITH MODIFIED CYCLOALKYLENYL CHAINS - HIGHLY POTENT AND ORALLY-ACTIVE ANTIANGINAL AGENTS

Authors
MATSUMURA Y ASAI T SHIMADA T NAKAYAMA T URUSHIHARA M MORIZAWA Y YASUDA A YAMAMOTO T FUJITANI B HOSOKI K
Citation
Y. Matsumura et al., NOVEL FLUOROPROSTACYCLIN ANALOGS WITH MODIFIED CYCLOALKYLENYL CHAINS - HIGHLY POTENT AND ORALLY-ACTIVE ANTIANGINAL AGENTS, Chemical and Pharmaceutical Bulletin, 43(2), 1995, pp. 353-355
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
2
Year of publication
1995
Pages
353 - 355
Database
ISI
SICI code
0009-2363(1995)43:2<353:NFAWMC>2.0.ZU;2-J
Abstract
Novel fluoroprostacyclin analogs (1a-f) have been synthesized and phar macologically evaluated. Compounds la-e given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal mo del.