TAXOL AND ITS RELATED TAXOIDS FROM THE NEEDLES OF TAXUS-SUMATRANA

Authors
KITAGAWA I MAHMUD T KOBAYASHI M",ROEMANTYO,"SHIBUYA H
Citation
I. Kitagawa et al., TAXOL AND ITS RELATED TAXOIDS FROM THE NEEDLES OF TAXUS-SUMATRANA, Chemical and Pharmaceutical Bulletin, 43(2), 1995, pp. 365-367
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
2
Year of publication
1995
Pages
365 - 367
Database
ISI
SICI code
0009-2363(1995)43:2<365:TAIRTF>2.0.ZU;2-E
Abstract
Through bioassay-guided separation of the chemical constituents of the needles of Taxus sumatrana, taxol (1), cephalomannine(2), and a new t axoid 19-hydroxy-13-oxobaccatin III (8) have been isolated together wi th 7-epi-10-deacetyltaxol (3), 7-epi-10-deacetylcephalomannine (4), ba ccatin III (5), 19-hydroxybaccatin III (6), and 10-deacetyl-13-oxobacc atin III (7). The chemical structure of 8 has been elucidated on the b ases of its chemical and physicochemical properties.