Three new neo-clerodane diterpenoids, 6 alpha-acetoxy-4 alpha,18-epoxy
-2 alpha-hydroxy-13-neocleroden-15,16-olide (2 alpha-hydroxyajugarin V
), 4 alpha,18-epoxy-2 alpha,6 alpha-dihydroxy-13-neocleroden-15,16-oli
de (2 alpha-hydroxy-deacetylajugarin V) and 2 alpha,6 alpha-dihydroxy-
4(18), 13-neoclerodadien-15,16-olide (scutedrummonin), have been isola
ted from the aerial parts of Scutellaria drummondii, in addition to th
e known flavone xanthomicrol. The structures of the new diterpenoids w
ere established by chemical and spectroscopic means, including X-ray d
iffraction analysis for 2 alpha-hydroxyajugarin V.