ALKYLATION OF PHOSPHATE GROUP OF NUCLEOTIDES VIA TRIBUTYLSTANNYL PHOSPHATE DERIVATIVES

Authors
AYUKAWA H OHUCHI S ISHIKAWA M HATA T
Citation
H. Ayukawa et al., ALKYLATION OF PHOSPHATE GROUP OF NUCLEOTIDES VIA TRIBUTYLSTANNYL PHOSPHATE DERIVATIVES, Chemistry Letters, (1), 1995, pp. 81-81
Citations number
2
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
1
Year of publication
1995
Pages
81 - 81
Database
ISI
SICI code
0366-7022(1995):1<81:AOPGON>2.0.ZU;2-Y
Abstract
Alkylation reaction of phosphates via tributylstannyl salt was applied to dinucleotide derivatives. Some alkyl groups were successfully intr oduced into the internucleotidic phosphate by use of alkyl bromides in the presence of tetraethylammonium bromide. In case of thymidylyl(3'- 5')thymidine, the phosphate moiety was alkylated selectively.