ASSOCIATIONS BETWEEN SERUM-LIPIDS AND INDICATORS OF ADIPOSITY IN MEN WITH SPINAL-CORD INJURY

Several reports indicate that dyslipidemia, primarily depressed high d ensity lipoprotein cholesterol, is common in persons with spinal cord injury. The purpose of this study was to assess the relationships betw een anthropometric and near infrared interactance measurements to the serum lipoprotein profiles of 46 men with spinal cord injury of > 6 mo nths duration. Mean age (+/- SD) was 49.5 +/- 15.0 y and duration of i njury was 17.5 +/- 13.0 y. Forty-one percent of the subjects had low h igh density lipoprotein cholesterol (< 35 mg dl(-1)) and 57% had eleva ted total cholesterol to high density lipoprotein cholesterol ratios ( > 4.5). Abdominal circumference was most closely associated with the o verall lipid profile and abdominal circumference/height ratio was the second strongest correlate. Body mass index, conicity index, and perce nt body fat estimated by near infrared interactance were significantly related to some lipid parameters; however, the relationships were wea ker than for abdominal circumference or abdominal circumference/height . Significant correlations were found between abdominal circumference and serum high density lipoprotein cholesterol (r = -0.421, P < 0.01) and log(10) triglyceride (r = 0.587, P < 0.001) concentrations as well as the total cholesterol:high density lipoprotein cholesterol (r = 0. 482, P < 0.01) and low density lipoprotein cholesterol-to-high density lipoprotein cholesterol (r = 0.387, P < 0.05) ratios. Based on these findings, the sample was partitioned by abdominal circumference into l ow (< 95 cm), moderate, and high (greater than or equal to 102 cm) ris k subgroups. Compared to the low risk group the high risk subjects had lower high density lipoprotein cholesterol (35 +/- 9 vs 44 +/- 9, P < 0.03) and higher triglyceride (173 +/- 71 vs 101 +/- 30.4 mg dl(-1), P < 0.003 for log(10) triglyceride, non-transformed values shown) and total cholesterol:high density lipoprotein cholesterol (5.6 +/- 1.8 vs 4.2 +/- 1.1, P < 0.03). Our results confirm those of earlier investig ators who found a high prevalence of depressed high density lipoprotei n cholesterol in men with spinal cord injury. In addition, these findi ngs suggest that abdominal adiposity, as indicated by abdominal circum ference or abdominal circumference/height ratio, is an important corre late of the dyslipidemia associated with SCI.