POLYMORPHISM OF THE MURINE INHIBITOR OF DIFFERENTIATION-CONTROLLING GENE, ID

The structure of Id was examined by Southern analysis in inbred mouse lines which included five subspecies of Mus musculus. No variation was detected within this species. The species Mus cookii shares the same form found in mice of M. musculus derivation, indicative of a long evo lutionary history and a common origin, However, five TaqI polymorphism s were found among several Mus species, suggesting that Id has been mo dified throughout species diversification. Whether these variants impa rt functional changes is yet to be determined.