We report a striking amino-acid sequence similarity between a chicken
extracellular matrix protein termed ES/130, involved in early cardiac
morphogenesis [Rezaee et al., J. Biol. Chem. 268 (1993) 14404-14411],
and a novel human protein termed CG-1, isolated from the glycoprotein
fraction of peripheral blood leukocytes [Print et al., Gene 144 (1994)
221-228]. These two proteins may be homologues which have evolved ove
r a period of 270 x 10(6) years.