SEQUENCE OF THE FUNCTIONAL HUMAN KERATIN K14 PROMOTER

Authors
STAGGERS WR PATERSON AJ KUDLOW JE
Citation
Wr. Staggers et al., SEQUENCE OF THE FUNCTIONAL HUMAN KERATIN K14 PROMOTER, Gene, 153(2), 1995, pp. 297-298
Citations number
5
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
153
Issue
2
Year of publication
1995
Pages
297 - 298
Database
ISI
SICI code
0378-1119(1995)153:2<297:SOTFHK>2.0.ZU;2-L
Abstract
The K14 keratin is an intermediate filament produced in squamous epith elia. This tissue-specific expression is directed by the promoter (pK1 4) of the K14 gene which has been used extensively to direct the expre ssion of transgenes to the skin. Human K14 was cloned and the upstream sequence is presented. In transient transfections, pK14 directs expre ssion of a luciferase reporter in keratinocytes much more potently tha n in breast cancer cells.