AN ADDITIONAL 5'-UPSTREAM EXON EXISTS IN THE HUMAN PLEIOTROPHIN-ENCODING GENE

Authors
LAI SP SCHULTE AM WELLSTEIN A RIEGEL AT
Citation
Sp. Lai et al., AN ADDITIONAL 5'-UPSTREAM EXON EXISTS IN THE HUMAN PLEIOTROPHIN-ENCODING GENE, Gene, 153(2), 1995, pp. 301-302
Citations number
7
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
153
Issue
2
Year of publication
1995
Pages
301 - 302
Database
ISI
SICI code
0378-1119(1995)153:2<301:AA5EEI>2.0.ZU;2-1
Abstract
A 2-kb 5' fragment of hPTN (human pleiotrophin-encoding) genomic DNA w as sequenced. Within this region we identified a new, upstream exon (U 2). Cloning and sequencing of the PCR products of cDNAs from a human m elanoma cell line revealed that a 401-bp intron was spliced out betwee n exon U2 and a previously described untranslated exon U1. Our analysi s also revealed that previously reported transcription start points (t sp) of PTN are located within exon U1.