LOCALIZATION OF THE HUMAN SOLUBLE EPOXIDE HYDROLASE GENE (EPHX2) TO CHROMOSOMAL REGION 8P21-P12

Epoxide hydrolases have an important function in organisms in that the y catalyze the transformation of potentially toxic or carcinogenic epo xides into the corresponding diols. In this study, the chromosomal loc alization was determined for the human gene encoding soluble epoxide h ydrolase. A polymerase chain reaction fragment corresponding to the C- terminal region of the mouse protein was used to isolate a cosmid clon e from a human genomic library. By fluorescence in situ hybridization to metaphase chromosomes, the soluble epoxide hydrolase gene was then localized to chromosomal region 8p21-p12.