INFLUENCE OF HIGH-DOSES OF VITAMIN-C ON THE BIOAVAILABILITY AND THE SERUM-PROTEIN BINDING OF LEVONORGESTREL IN WOMEN USING A COMBINATION ORAL-CONTRACEPTIVE
W. Kuhnz et al., INFLUENCE OF HIGH-DOSES OF VITAMIN-C ON THE BIOAVAILABILITY AND THE SERUM-PROTEIN BINDING OF LEVONORGESTREL IN WOMEN USING A COMBINATION ORAL-CONTRACEPTIVE, Contraception, 51(2), 1995, pp. 111-116
The absence of an effect of high oral doses of vitamin C on the system
ic availability of ethinylestradiol in women using a levonorgestrel-co
ntaining combination oral contraceptive (0.15 mg levonorgestrel and 0.
03 mg ethinylestradiol) was demonstrated in a recent study. However, i
t is conceivable that the oral administration of gram quantities of vi
tamin C could also interfere with the sulfation of levonorgestrel (LNG
) metabolites during phase II biotransformation, because sulfates repr
esent a major part of the conjugated metabolites of LNG in the serum.
This possible interaction was investigated in the aforementioned study
, comparing Cmax and AUC(0-12h) values of LNG on the first and 15th da
y of two successive treatment cycles with and without co-medication of
vitamin C. In addition, the serum protein binding of LNG and the conc
entration of the binding proteins SHBG and CBG were compared between b
oth treatments. Corresponding parameters obtained during treatment wit
h the oral contraceptive alone and during co-administration of vitamin
C were evaluated statistically for possible differences. No effect of
vitamin C was observed for any of the parameters investigated. Thus,
the repeated oral administration of gram quantities of vitamin C does
not impair the sulfation of hydroxylated metabolites of LNG. There was
also no observable effect on the serum protein binding of LNG and the
concentrations of SHBG and CBG in the serum. The results obtained in
this study population (American women) for LNG are in good agreement w
ith those obtained from a previous study in European women, who had ta
ken a combination oral contraceptive containing the same doses of LNG
and ethinylestradiol.