SYNTHESIS OF NEVIRAPINE AND ITS MAJOR METABOLITE

Authors
GROZINGER KG FUCHS V HARGRAVE KD MAULDIN S VITOUS J CAMPBELL S ADAMS J
Citation
Kg. Grozinger et al., SYNTHESIS OF NEVIRAPINE AND ITS MAJOR METABOLITE, Journal of heterocyclic chemistry, 32(1), 1995, pp. 259-263
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
1
Year of publication
1995
Pages
259 - 263
Database
ISI
SICI code
0022-152X(1995)32:1<259:SONAIM>2.0.ZU;2-G
Abstract
Several synthetic methods were developed during the process optimizati on for the large scale synthesis of nevirapine (1), a non-nucleoside i nhibitor of HIV-1 Reverse Transcriptase. The synthesis of its putative major metabolite ydroxymethyl-6H-[3,2-b:2',3'-e][1,4]diazepin-6-one ( 2) and the oxidation of 2 to the corresponding aldehyde 3, are describ ed.