HETEROCYCLIC STEROIDS - SYNTHESIS OF ANDROSTENO[17,16-D]PYRAZOLES ANDANDROSTENO[17,16-E]PYRIMIDINES

Authors
SIDDIQUI AU RAO VUM MAIMIRANI M SIDDIQUI AH
Citation
Au. Siddiqui et al., HETEROCYCLIC STEROIDS - SYNTHESIS OF ANDROSTENO[17,16-D]PYRAZOLES ANDANDROSTENO[17,16-E]PYRIMIDINES, Journal of heterocyclic chemistry, 32(1), 1995, pp. 353-354
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
1
Year of publication
1995
Pages
353 - 354
Database
ISI
SICI code
0022-152X(1995)32:1<353:HS-SOA>2.0.ZU;2-K
Abstract
The Vilsmeier-Haack reaction of 3beta-acetoxyandost-5-en-17-one (1) wi th phosporous oxychloride and dimethylformamide gave 3beta-acetoxy-17- chloro-16-formylandrosta-5, 16-diene (2). Reaction of 2 with hydrazine and phenylhydrazine provided substituted 5-androsteno[17,16-d]pyrazol es 3 and 4 respectively. Similarly, condensation of 2 with urea and gu anidine hydrochloride revealed the formation of the corresponding subs tituted pyrimidines 5 and 6 respectively.